604 research outputs found
The use of isoxazoline and isoxazole scaffolding in the design of novel thiourea and amide liquid-crystalline compounds
The authors wish to thank the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001 for the fellowships and Conselho Nacional de Pesquisa Cientifica (CNPq, edital Universal) for the financial support grant n. 403075 2016-5.A series of novel thiourea and amide liquid crystals containing 5-membered isoxazoline and isoxazole rings were synthetized and the liquid crystal properties studied. Thioureas were obtained using a condensation reaction of benzoyl chlorides, arylamines and ammonium thiocyanate. The amides, on the other hand, were the byproduct of a quantitative reaction which used potassium cyanate as the starting material. Thiourea and amide derivatives were predominantly SmA mesophase inductors. A nematic mesophase was observed only for thioureas and amides containing an isoxazole ring. Additionaly, the liquid crystal behavior was also dependent on the relative position of nitrogen and oxygen atoms on the 5-membered heterocycle.publishersversionpublishe
Evidence for the accelerated expansion of the Universe from weak lensing tomography with COSMOS
We present a tomographic cosmological weak lensing analysis of the HST COSMOS
Survey. Applying our lensing-optimized data reduction, principal component
interpolation for the ACS PSF, and improved modelling of charge-transfer
inefficiency, we measure a lensing signal which is consistent with pure
gravitational modes and no significant shape systematics. We carefully estimate
the statistical uncertainty from simulated COSMOS-like fields obtained from
ray-tracing through the Millennium Simulation. We test our pipeline on
simulated space-based data, recalibrate non-linear power spectrum corrections
using the ray-tracing, employ photometric redshifts to reduce potential
contamination by intrinsic galaxy alignments, and marginalize over systematic
uncertainties. We find that the lensing signal scales with redshift as expected
from General Relativity for a concordance LCDM cosmology, including the full
cross-correlations between different redshift bins. For a flat LCDM cosmology,
we measure sigma_8(Omega_m/0.3)^0.51=0.75+-0.08 from lensing, in perfect
agreement with WMAP-5, yielding joint constraints Omega_m=0.266+0.025-0.023,
sigma_8=0.802+0.028-0.029 (all 68% conf.). Dropping the assumption of flatness
and using HST Key Project and BBN priors only, we find a negative deceleration
parameter q_0 at 94.3% conf. from the tomographic lensing analysis, providing
independent evidence for the accelerated expansion of the Universe. For a flat
wCDM cosmology and prior w in [-2,0], we obtain w<-0.41 (90% conf.). Our dark
energy constraints are still relatively weak solely due to the limited area of
COSMOS. However, they provide an important demonstration for the usefulness of
tomographic weak lensing measurements from space. (abridged)Comment: 26 pages, 25 figures, matches version accepted for publication by
Astronomy and Astrophysic
Generalized compactness in linear spaces and its applications
The class of subsets of locally convex spaces called -compact sets is
considered. This class contains all compact sets as well as several noncompact
sets widely used in applications. It is shown that many results well known for
compact sets can be generalized to -compact sets. Several examples are
considered.
The main result of the paper is a generalization to -compact convex sets
of the Vesterstrom-O'Brien theorem showing equivalence of the particular
properties of a compact convex set (s.t. openness of the mixture map, openness
of the barycenter map and of its restriction to maximal measures, continuity of
a convex hull of any continuous function, continuity of a convex hull of any
concave continuous function). It is shown that the Vesterstrom-O'Brien theorem
does not hold for pointwise -compact convex sets defined by the slight
relaxing of the -compactness condition. Applications of the obtained
results to quantum information theory are considered.Comment: 27 pages, the minor corrections have been mad
Astrometric calibration and performance of the Dark Energy Camera
We characterize the ability of the Dark Energy Camera (DECam) to perform
relative astrometry across its 500~Mpix, 3 deg^2 science field of view, and
across 4 years of operation. This is done using internal comparisons of ~4x10^7
measurements of high-S/N stellar images obtained in repeat visits to fields of
moderate stellar density, with the telescope dithered to move the sources
around the array. An empirical astrometric model includes terms for: optical
distortions; stray electric fields in the CCD detectors; chromatic terms in the
instrumental and atmospheric optics; shifts in CCD relative positions of up to
~10 um when the DECam temperature cycles; and low-order distortions to each
exposure from changes in atmospheric refraction and telescope alignment. Errors
in this astrometric model are dominated by stochastic variations with typical
amplitudes of 10-30 mas (in a 30 s exposure) and 5-10 arcmin coherence length,
plausibly attributed to Kolmogorov-spectrum atmospheric turbulence. The size of
these atmospheric distortions is not closely related to the seeing. Given an
astrometric reference catalog at density ~0.7 arcmin^{-2}, e.g. from Gaia, the
typical atmospheric distortions can be interpolated to 7 mas RMS accuracy (for
30 s exposures) with 1 arcmin coherence length for residual errors. Remaining
detectable error contributors are 2-4 mas RMS from unmodelled stray electric
fields in the devices, and another 2-4 mas RMS from focal plane shifts between
camera thermal cycles. Thus the astrometric solution for a single DECam
exposure is accurate to 3-6 mas (0.02 pixels, or 300 nm) on the focal plane,
plus the stochastic atmospheric distortion.Comment: Submitted to PAS
Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.
Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy
Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population
In the current model of early Solar System evolution, the stable members of
the Jovian and Neptunian Trojan populations were captured into resonance from
the leftover reservoir of planetesimals during the outward migration of the
giant planets. As a result, both Jovian and Neptunian Trojans share a common
origin with the primordial disk population, whose other surviving members
constitute today's trans-Neptunian object (TNO) populations. The cold classical
TNOs are ultra-red, while the dynamically excited "hot" population of TNOs
contains a mixture of ultra-red and blue objects. In contrast, Jovian and
Neptunian Trojans are observed to be blue. While the absence of ultra-red
Jovian Trojans can be readily explained by the sublimation of volatile material
from their surfaces due to the high flux of solar radiation at 5AU, the lack of
ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation
models. In this work we report the discovery by the Dark Energy Survey (DES) of
two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both
with inclinations i >30 degrees, making them the highest-inclination known
stable Neptunian Trojans. We have measured the colors of these and three other
dynamically stable Neptunian Trojans previously observed by DES, and find that
2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such,
2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using
a simulation of the DES TNO detection efficiency, we find that there are 162
+/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the
blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based
on this result, we discuss the possible origin of the ultra-red Neptunian
Trojan population and its implications for the formation history of Neptunian
Trojans
Phenotypic redshifts with self-organizing maps: A novel method to characterize redshift distributions of source galaxies for weak lensing
Wide-field imaging surveys such as the Dark Energy Survey (DES) rely on
coarse measurements of spectral energy distributions in a few filters to
estimate the redshift distribution of source galaxies. In this regime, sample
variance, shot noise, and selection effects limit the attainable accuracy of
redshift calibration and thus of cosmological constraints. We present a new
method to combine wide-field, few-filter measurements with catalogs from deep
fields with additional filters and sufficiently low photometric noise to break
degeneracies in photometric redshifts. The multi-band deep field is used as an
intermediary between wide-field observations and accurate redshifts, greatly
reducing sample variance, shot noise, and selection effects. Our implementation
of the method uses self-organizing maps to group galaxies into phenotypes based
on their observed fluxes, and is tested using a mock DES catalog created from
N-body simulations. It yields a typical uncertainty on the mean redshift in
each of five tomographic bins for an idealized simulation of the DES Year 3
weak-lensing tomographic analysis of , which is a
60% improvement compared to the Year 1 analysis. Although the implementation of
the method is tailored to DES, its formalism can be applied to other large
photometric surveys with a similar observing strategy.Comment: 24 pages, 11 figures; matches version accepted to MNRA
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